How long does it take for Oxycontin to kick in? A common drug that falls under the category of synthetic opioids is Oxycontin. Oxycontin works by interacting with our stimulating receptors in the brain and the spinal cord which leads to the body and the brain perceiving pain in a different manner. If you have been given a prescription of Oxycontin, you might be wondering how long will Oxycontin kick in and for how long will it last. This...