The latest research study "Cell-free Protein Expression Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2023-2028" by IMARC Group, finds that The global cell-free protein expression market size reached US$ 246.5 Million in 2022. Looking forward, IMARC Group expects the market to reach US$ 323.8 Million by 2028, exhibiting a growth rate (CAGR) of 7.61% during 2023-2028.

Cell-free protein expression (CFPE) represents the production of selected recombinant proteins in solution using biomolecular translation machinery pulled from cells. It can be carried out using various cell lysates, such as rabbit reticulocytes, wheat germ, insect cells, E. coli, and mammalian systems. CFPE is extensively used in protein labeling and purification, enzyme engineering, protein-protein interaction, and high throughput production of mutants. It is also used for analyzing components needed for protein degradation, stability, and folding. Compared to a cell-based expression system, CFPE allows the incorporation of non-natural amino acids, is time efficient and convenient, and provides enhanced stability and specificity. As a result, this technique finds widespread applications in pharmaceutical and biotechnology companies and academic and research institutes. 

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Note: We are regularly tracking the direct effect of COVID-19 on the market, along with the indirect influence of associated industries. These observations will be integrated into the report.

Cell-free Protein Expression Market Trends and Drivers:

The rising advancement in biological sciences is among the primary factors driving the cell-free protein expression market. Besides this, the escalating need for this technique in the assembly of viruses, expansion of genetic code, and the synthesis of recombinant proteins for various biomolecular processes is further augmenting the market growth. Moreover, the introduction of innovative methods to produce complex prokaryotic and eukaryotic proteins using a continuous-exchange cell-free (CECF) synthesis system is also catalyzing the global market. Apart from this, the elevating demand for this procedure in the pharmaceutical industry for developing protein-based therapeutics, including antibodies, antimicrobials, and cytokines, for treating cancer and infectious diseases is acting as another significant growth-inducing factor. Additionally, the incorporation of machine learning (ML) algorithms to enhance protein yield by optimizing the system for efficient prototyping and high-throughput experimentation is also stimulating the market growth. Furthermore, the growing popularity of this technique in biomanufacturing and prototyping and the extensive research and development (R&D) activities in genomics and proteomics are expected to bolster the cell-free protein expression market in the coming years. 

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Cell-free Protein Expression Market 2023-2028 Analysis and Segmentation:

Competitive Landscape:

The competitive landscape of the market has been studied in the report with the detailed profiles of the key players operating in the market.

Bioneer Corporation, biotechrabbit GmbH, Cambridge Isotope Laboratories Inc. (Otsuka Pharmaceutical Co. Ltd.), CellFree Sciences Co. Ltd., Cube Biotech GmbH, GeneCopoeia Inc., Jena Bioscience GmbH, Merck KGaA, New England Biolabs, Promega Corporation, Takara Bio Inc. and Thermo Fisher Scientific Inc.

The report has segmented the market on the basis of 

Breakup by Product:

  • Expression Systems
    • E. coli Cell-free Protein Expression System
    • Wheat Germ Cell-free Protein Expression System  
    • Rabbit Reticulocytes Cell-free Protein Expression System  
    • Insect Cells Cell-free Protein Expression System    
    • Human Cell-free Protein Expression System
    • Others
  • Reagents

Breakup by Method:

  • Transcription and Translation Systems 
  • Translation Systems

Breakup by Application:

  • Enzyme Engineering
  • High Throughput Production
  • Protein Labeling
  • Protein-Protein Interaction
  • Protein Purification

Breakup by End User:

  • Pharmaceutical and Biotechnology Companies
  • Academic and Research Institutes
  • Others

Breakup by Region:

  • North America: (United States, Canada)
  • Asia Pacific: (China, Japan, India, South Korea, Australia, Indonesia, Others)
  • Europe: (Germany, France, United Kingdom, Italy, Spain, Russia, Others)
  • Latin America: (Brazil, Mexico, Others)
  • Middle East and Africa

Key highlights of the report:

  • Market Performance (2017-2022)
  • Market Outlook (2023- 2028)
  • Porter's Five Forces Analysis
  • Market Drivers and Success Factors
  • SWOT Analysis
  • Value Chain
  • Comprehensive Mapping of the Competitive Landscape

If you need specific information that is not currently within the scope of the report, we can provide it to you as a part of the customization.

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