After taking a back seat for a fortnight at the expense of cup competitions, the Premier League returns to action this weekend.From Manchester Citys home clash against Chelsea to Arsenals trip to Tottenham Derek Watt Jersey Hotspur, several cracking match-ups are scheduled for the next couple of days.Lets take a look at the three most exciting fixtures to watch out for as well as our on the winners this weekend.Manchester City vs ChelseaA blockbuster meeting between City and Chelsea at the Etihad Stadium will serve to launch Saturdays Premier League action. Coming into this matchday, the defending English champions boast a substantial ten-point lead over the reigning Champions League holders and could put the title race firmly to bed with a win here.Pep Guardiola Cameron Sutton Jersey s side claimed a in the reverse fixture at Stamford Bridge as they now aim to complete their fourth top-flight double over this opposition.The Cityzens head into proceedings amid a purple patch, having won their last 11 league matches in a row by an aggregate score of 33-7, with 64% of those triumphs yielding a margin of 2+ goals.In the meantime, the Blues are currently enjoying a six-game unbeaten run in the Premier League (W2, D2), albeit they have drawn their last two league outings in a row.Prediction: Man Karl Joseph Jersey City 2-1 ChelseaWest Ham United vs Leeds UnitedLeeds United have an immediate opportunity to gain revenge on West Ham United after last weekends clear-cut 2-0 FA Cup defeat at the London Stadium.The sides will meet in contrasting circumstances. While the Hammers remain firmly in contention for their first-ever top-four finish in Englands top-flight, the Whites are dancing on the edge of relegation.Marcelo Bielsas men sit eight points clear of 18th-placed Burnley in Kordell Stewart Jersey the , but the Clarets have two games in hand, meaning Leeds life could grow increasingly untenable in the second half of the season.However, the visitors can draw confidence from a landslide 3-1 win over non-other than Burnley last time out, as they now target back-to-back league victories for the first time this season.That could be easier said than done, considering they have lost all three top-flight encounters against West Ham since returning to the Premier League last season.Prediction: West Ham 2-0 LeedsTottenham Hotspur vs ArsenalSundays Premier League action closes out with an all-London showdown between high-flying Tottenham and Arsenal at the Tottenham Hotspur Stadium Jack Lambert Jersey .Only two points separate the sides ahead of the kick-off, with sixth-placed Spurs boasting two games in hand.Tottenham have enjoyed quite a renai sance under new bo s Antonio Conte, going unbeaten in all eight Premier League matches under the Italians stewardship (W5, D3).Both teams have realistic chances of landing a coveted top-four finish this season, and this clash could provide an insight into their Champions League credentials.Arsenal turned a 1-0 half-time lead into a 2-1 defeat to Man City on New Years Day, ending a run of four league victories as they now sit a point adrift of fourth-placed West Ham.To get James Washington Jersey back to winning ways, the Gunners will have to defy their embarra sing seven-game winle s streak at Tottenham (D2, L5), conceding precisely twice in five of those fixtures.Prediction: Tottenham 1-1 Arsenal