When the Jaguars travel to face the Jets to open Week 16 on "Thursday Night Football" (8:15 p.m. ET, Amazon Prime Video), it's a battle of two AFC playoff hopefuls going in different directions. That sets up some interesting start 'em, sit 'em concerns for fantasy football owners needing to maximize points in seasonal-league playoffs.Jacksonville comes with red-hot Trevor Lawrence, the top-overall pick from 2021, who has become a strong QB1 on the season after lighting up Tenne see and Dallas Tony Phillips Jersey the past two weeks. New York will once again turn back to their struggling second-overall pick from '21, QB Zach Wilson, who just dragged down the offense vs. Detroit in relief duty of an injured Mike White (ribs).The Jaguars have concerns against New York's tough defense with left tackle Cam Robinson (knee) going down for the season, but their offensive skill weapons are rolling. The Jets' defense was a little more giving against the Lions while their offense mostly tanked. There is rain in the forecast for Thursday night, but it will be warmer than usual in the high 40s with what looks like manageable winds.With all that in mind, here's a fantasy football breakdown of what should be a medium-scoring matchup:WEEK 16 FANTASY PICKS: | | Sit: QB Zach WilsonIt's easy Kendall Graveman Jersey to think Wilson should be better as we watch fellow second-year QBs Justin Fields and Trevor Lawrence blow up, but he just can't seem to put his pa sing or running together because of his impatience, indecision, and inaccuracy. White not playing has been a total drag.MORE TNF: | Start: RB Zonovan Knight"Bam" was slowed against the Lions and was banged up a bit after Sunday's game, but the Jaguars have been more giving on the ground of late and he will still get the key volume. Let's hope he's more "Bam" than bust this week.WEEK 16 STANDARD RANKINGS: | | | | | Sit: RB Michael CarterCarter had a great opportunity with Breece Hall (knee) down and James Robinson not looking good with his new team. But unfortunately, Zonovan zoomed ahead of him, and when Knight wasn't doing much last week, Carter's production was still at a stalemate.Start: WRs Garrett Wilson and Elijah Moore | Sit: WR Corey DavisDavis is set to return from his latest injury (concu sion), and for what it's worth, has the "best" chemistry with Zach Wilson, but the youthful Garrett Wilson and Moore are the real playmakers to get involved. Wilson is now transcending as a No. 1, while Moore could use more grease in the slot. Wilson is the obvious high-ceiling play; Moore is the squeaky-and-sneaky floor play.WEEK 16 PPR RANKINGS: | | | | | Sit: TEs Tyler Conklin and C.J. UzomahThe tight end committee seemed to be more Conklin early, then a healthy Uzomah dropped two TDs on the Lions. You just can't go here Joe Morgan Jersey with the risk of next to nothing.WEEK 16 DFS LINEUPS: | Start: K Greg ZuerleinGreg the Leg didn't have enough leg to tie the game vs. the Lions. He also doesn't have legs in our lineup with some weather on the way on a low-scoring team.Sit: Jets D/STThe Cowboys D/ST didn't come through against the Jags last week, Reggie Jackson Jersey even with some key plays. The Jets have run into better offenses late and become unplayable.WEEK 16 DFS: | Start: QB Trevor LawrenceLawrence is having a stellar all-around breakout season for reality and fantasy. He has made the jump from sleeper QBs to bona fide QB1. Pederson and Pre s Taylor have done a great job, and he keeps improving with more confidence each week. Don't expect a third-straight huge game, but his pa sing and running will add up to a solid night of two TDs.Start: RB Travis Etienne Jr.It was good to see him running well again against the Cowboys and also get a little more involved in the pa sing game. He seems to be fully healthy again with open-field burst and underrated power running. He gets too much volume to sit, even though the yardage might be more of a grind.Start: WR Marcus Semien Jersey Christian KirkKirk's slot value will bump up again in this matchup away from cornerbacks Sauce Gardner and D.J. Reed outside. He should be busy on shorter pa ses vs. the zone.Start: WR Zay Jones | Sit: WR Marvin Jones Jr.Zay won't score three TDs again and can see a considerable cool-off after his Cowboys domination, but as a WR2 on the season, he can be started as a WR3. Marvin definitely won't score for a second straight week.Start: TE Evan EngramEngram is back working into the intermediate pa sing offense, and he should help Kirk on short-to-intermediate routes inside with more production than the Joneses. Tight end is such a brutal position, he stands out too much to sit.Sit: K Riley PattersonPatterson is no relation to Paterson, New Jersey, which is about 20 minutes from MetLife Stadium. He also is no relevance to your fantasy team despite being a good kicker.Start: Jaguars D/STThe Jaguars' defense won the Week 15 game in overtime with Rayshawn Jenkins' pick-six vs. Dak Prescott. They should be licking their chops to pre sure Wilson into mistakes. MVP (1.5X): WR Garrett Wilson $13,500AnyFLEX: QB Trevor Lawrence $16,500AnyFLEX: WR Christian Kirk$13,000AnyFLEX: Jaguars D/ST $9,000AnyFLEX: WR Elijah Moore$7,500Here's figuring Lawrence to Kirk will help the Jaguars build a lead and force the Jets to throw often to Wilson and Moore, which also opens the door for the Jags' D/ST to make big plays. Captain (1.5X): WR Garrett Wilson $13,500FLEX: QB Trevor Lawrence$11,400FLEX: WR Christian Kirk$10,200FLEX: TE Evan Engram $7,600FLEX: WR Elijah Moore $4,800FLEX: WR Jamal Agnew$2,000This is a very similar construction to FD, with four of the Jose Canseco Jersey same players. We added in Engram to attack that zone defense inside, and there was just room for a cheap flier on Agnew, who doesn't need to do much to return 3X value.