The 2022 NFL season is finally here. There will be a total of 272 games played this season before we get to the playoffs, and the first of those games sees the defending champion begin their title defense by welcoming one of this season's favorites -- the -- to SoFi Stadium on Thursday evening.In what projects to be a thrilling debut contest, we will see stars all over the field. From and to and , and and to and and , the gridiron will be overflowing with some of the league's best players. There could hardly be a better way to open this campaign.Before we get to breaking down the matchup, here's how you can watch the game on Thursday night.Date:Thursday, Sept. 8|Time:8:20 p.m. ETLocation:SoFi Stadium (Inglewood, California) TV:NBC|Stream:fuboTV ( )Follow:Odds Greg Olsen Jersey :Bills -2.5, O/U 52 When the Bills have the ballBefore we get into discu sing the various stars around which the matchups on this side of the ball will orbit, it's important to talk about structure.No defense in the league played more early-down (first and second) snaps with six or fewer defenders in the box last season than did the Rams, according to Tru Media. Buffalo's offense, meanwhile, saw opponents play with light boxes on early downs more often than all but two other . So, the Bills are used to seeing this defensive posture -- and finding succe s against it, as they finished the season ranked eighth in EPA per play on those snaps.Beginning under Brandon Staley and now under Raheem Morris, Los Angeles first and foremost wants to take away the deep pa s, and structuring the defense this way allows them to do so while -- for the last two seasons, at least -- not giving up too much in the run game. Without players like up front, it will be interesting to see if Morris can still play things Kamal Martin Jersey the same way, or if he has to change to more traditional four-man defensive lines and maybe even drop a safety down into the box more often than he would like to. Either way, the Rams would surely prefer that the Bills put the ball in the hands of , , or than those of Josh Allen. The Bills, though, have an interesting counter available to them -- using Allen as, e sentially, a running back. We saw them do this in their early-season game against the last season, when Allen had 11 carries for 59 yards and a touchdown, and played a huge role in the Bills marching directly down the field for a touchdown on their opening drive of the game. Allen had 31 designed runs against six-or-fewer men in the box last season, the most of any quarterback. He averaged 6.4 yards per carry on those plays, an elite mark by any measure.The Bills over the second half of the season also utilized heavier personnel groupings to give themselves better numbers in the run game, and also to open up play-action pa sing against linebackers. It proved quite succe sful, and we could see more of that against the Rams. Over the second half of the season, Allen also proved more willing to check the ball down to secondary targets and let them make plays after the catch. Buffalo specifically targeted pa s-catching backs this offseason to aid in that style of play, first pursuing in free agency, then signing and drafting James Cook. If Cook (or Johnson, if he's active) can make the first man mi s off a swing pa s or checkdown (a difficult task against the lines of and ), that could prove very useful.Buffalo's other counter against the "take away deep shots" style defense was to simply throw the ball all the way over the top of them. Allen was 13 of 31 for 534 yards and two touchdowns on throws of at least 30 air yards during the regular season, and we saw against both the and the Chiefs that he has both the arm strength and confidence to sling the ball as far as he can, and the trust in his receivers to come down with it. How Carolina Panthers Jersey the Rams elect to play things on the back end against Stefon Diggs, Gabe Davis, , , and also bears watching. Morris used Jalen Ramsey in the slot more often than did Staley, but Diggs doesn't line up there all that often; he did so on only 21 percent of his routes last season. McKenzie seems likely to open the season as the primary slot man. Is getting Ramsey closer to the ball and the line of scrimmage worth as much if he's going to spend the majority of his time coverage Buffalo's shiftiest wideout, but one who is nonethele s the third or fourth option in the pa sing game? And can Morris trust and to hold up against Diggs and Davis on the perimeter? Morris did not use Carolina Panthers Hoodies Sweatshirts Ramsey to shadow receivers last season, but it might be worth considering in this matchup.Of course, Allen needs to have ample time to actually throw the ball to those wideouts, and that could be more difficult than imagined. Aaron Donald is capable of single-handedly wrecking any game plan, and the games where Buffalo struggled offensively last season were those where the offensive line was simply overwhelmed by the opposing defensive front. How well the interior of that line can hold up against the best player in the game is perhaps the single-most important factor in Buffalo's offensive succe s.When the Rams have the ballThe big thing to watch here is how the Bills' defensive backfield handles the Matthew Stafford-Cooper Kupp connection, and whether the Rams' other receivers can take advantage of the attention that must be paid to the league's most productive receiver from last season. Buffalo will be without star cornerback , who is still recovering from an ACL tear he suffered last season. That leaves two rookies -- first-round pick and sixth-round pick -- in line for heavy playing time alongside and . Will the Bills be able to play as much man coverage as they typically like to (just three teams played man at a higher rate on early downs last season, according to Tru Media) without their star corner? Considering Kupp had 24 more receptions against zone coverage last season than any other player in the league, it might be advisable to avoid letting him just find soft spots in between defenders.The thing Stafford really elevated for the Rams last season was their ability to connect on big plays down the field. A year after went just 13 of 49 on throws at least 20 yards down the field, Stafford Brady Christensen Jersey completed 31 of 73 such attempts and tied for the fifth-best EPA per play in the league on those dropbacks. The Bills, though, were better than any team in the at limiting big plays in the pa sing game. Buffalo allowed just 10 completions of 20 or more air yards all of last season, limiting opponents to a hilarious 10 of 45 for 283 yards, zero touchdowns, and seven interceptions on those pa ses. With Micah Hyde and Jordan Poyer still patrolling the deep portion of the field, the Rams may have to attack the short and intermediate areas more often; and if the Bills have to play more zone due to their lack of experience a