The humanized mice model market (ヒト化マウスモデル市場) is forecasted to achieve a valuation of US$ 101.6 million by 2024, with projections indicating a steady surge at a compound annual growth rate (CAGR) of 6.0%. By 2034, the market is anticipated to escalate to US$ 182.0 million, demonstrating sustained growth momentum.

The humanized mice model market has emerged as a vital tool in biomedical research and drug development, facilitating the translation of findings from preclinical studies to clinical applications. These models, genetically engineered to carry functional human genes, tissues, or cells, simulate human physiology and pathophysiology more accurately than traditional animal models. As the demand for personalized medicine and targeted therapies continues to rise, the humanized mice model market is expected to witness significant growth, driven by advancements in genetic engineering technologies, increasing investment in research and development, and the expanding scope of applications across various therapeutic areas.

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Market Dynamics

One of the primary drivers propelling the humanized mice model market (인간화 마우스 모델 시장) is the pressing need for more accurate preclinical models in drug discovery and development. Conventional animal models often fail to accurately predict human responses to drugs, leading to high rates of clinical trial failures and substantial financial losses for pharmaceutical companies. Humanized mice models offer a solution by allowing researchers to study the efficacy and safety of potential therapeutics in a more human-relevant context, thereby improving the likelihood of successful translation to clinical trials.

Moreover, the rise of precision medicine and the growing emphasis on patient stratification have increased the demand for personalized animal models that can mimic specific disease states or genetic backgrounds. Humanized mice models can be tailored to express patient-specific mutations or to harbor human immune cells for studying diseases such as cancer, autoimmune disorders, and infectious diseases. This customization enhances the relevance and translational potential of preclinical research findings, fostering more targeted and effective therapeutic interventions.

Furthermore, technological advancements in genetic engineering techniques, such as CRISPR-Cas9, have significantly expanded the capabilities and versatility of humanized mice models. Researchers can now create more sophisticated models with precise genetic modifications, allowing for the study of complex diseases and therapeutic targets with greater accuracy and efficiency. Additionally, collaborations between academia, biotechnology companies, and contract research organizations have facilitated the development and commercialization of novel humanized mice models, driving market growth.

List of Key Companies Profiled in The Report

  • THE JACKSON LABORATORY
  • laconic Biosciences Inc.
  • Genoway S.A.
  • Yecuris Corporation
  • Charles River Laboratories Inc.
  • Crown Bioscience Inc.
  • Ingenious Targeting Laboratory Inc.
  • orizon Discovery Group plc
  • HuMurine Technologies
  • Trans Genic Inc. Ltd.

Market Future Outlook

The future outlook for the humanized mice model market (marché modèle de souris humanisées) is promising, with continued growth expected as the demand for more physiologically relevant preclinical models intensifies. As the limitations of traditional animal models become increasingly apparent, pharmaceutical companies and research institutions are investing in advanced humanized mice models to improve the efficiency and success rates of drug discovery and development pipelines.

Moreover, the expanding applications of humanized mice models across diverse therapeutic areas, including oncology, immunology, infectious diseases, and regenerative medicine, are expected to drive market growth. With the advent of immuno-oncology therapies and the growing interest in cell-based therapies, there is a growing need for preclinical models that can accurately recapitulate the complexities of the human immune system and tumor microenvironment. Humanized mice models equipped with humanized immune systems offer a valuable platform for studying immune-oncology interactions, evaluating novel cancer immunotherapies, and optimizing treatment strategies for individual patients.

Additionally, the emergence of gene editing technologies and the increasing availability of humanized mice strains with specific genetic backgrounds or disease phenotypes will further expand the utility and applications of these models. Researchers are exploring novel approaches to enhance the humanization of mice by incorporating human organoids or organ-on-chip technologies into existing models, enabling more comprehensive studies of organ-specific diseases and drug responses.

Market Insights

Recent market insights suggest that North America dominates the global humanized mice model market, owing to the presence of a robust biomedical research infrastructure, strong funding support from government agencies and private investors, and a high concentration of pharmaceutical and biotechnology companies. However, Asia-Pacific is poised to emerge as a lucrative market for humanized mice models, driven by increasing investment in life sciences research, a growing biotechnology sector, and rising demand for preclinical models in drug development and personalized medicine initiatives.

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Moreover, the COVID-19 pandemic has underscored the importance of humanized mice models in infectious disease research and vaccine development. These models have played a crucial role in studying the pathogenesis of SARS-CoV-2, evaluating potential therapeutics, and assessing vaccine efficacy, highlighting their significance in addressing global health challenges.

Recent Developments

The humanized mice model market features a dynamic competitive landscape, with leading companies prioritizing research and development alongside the introduction of new formulations to bolster their market presence.

Key players are also placing emphasis on environmentally friendly practices, securing product certifications, and meeting the surging demand for personalized medication. These companies are keen on maintaining their market dominance and leveraging the expanding market by concentrating on product quality and innovation.

For example:

In October 2021, The Jackson Laboratory (JAX), a non-profit biomedical research organization based in the United States, acquired Charles River Laboratories Japan's Research Models & Services (RMS) division, integrating it as a wholly-owned subsidiary.

In February 2019, H.I.G. Capital LLC, through one of its affiliates, completed the acquisition of Taconic Biosciences Inc., indicating a strategic move to strengthen their position in the market.

In November 2020, The Jackson Laboratory partnered with Beijing Anitec Biotechnology to establish a joint venture aimed at enhancing accessibility and expediting the provision of high-quality research models and services in China.

Humanized Mice Model Market Segmentation by Category

  • By Model Type:

    • Genetic

    • Cell-based

  • By Application:

    • Toxicology

    • Oncology

    • Infectious Disease

    • GvHD

    • Regenerative Medicine

    • Neurobiology

    • Others

  • By End-user:

    • Pharmaceutical and Biotechnology Companies

    • Contract Research Organizations

    • Academic & Research Institutes

  • By Region:

    • North America

    • Latin America

    • Eastern Europe

    • Western Europe

    • South Asia and the Pacific

    • East Asia

    • Middle East and Africa

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