MLB Opening Day 2021 arrives Thursday with a ma sive 15-game schedule that gets underway. Aces like , and are scheduled to take the hill, meaning there will be plenty of challenges when making your 2021 picks Dillon Brooks Jersey for Opening Day. Should you expect those power arms to shut down opposing lineups, or is there value in one of them getting shelled and bringing a large return on the money line?The latest MLB odds for 2021 Opening Day from William Hill Sportsbook list Cole and the at -177 (risk $177 to win $100) against the , while Bieber and the are -190 against the . Other Justise Winslow Jersey MLB lines of note include deGrom and the at -145 against the and the listed as slim money-line favorites (-111) against the . Before making any MLB picks or predictions on those games or others, you need to .The renowned co-founder of Accuscore, Oh has dominated three straight seasons, returning $3,178 to $100 bettors, and his models simulate Kyle Anderson Jersey every pitch of every game 10,000 times. Now, Oh has crunched the numbers for Thursday's 2021 MLB Opening Day using his projection model and has posted his best bets. .Top MLB Opening Day expert picksOh likes Brandon Clarke Jersey the at +196 on the money line against the . Veteran lefty gets the start for Arizona. While he didn't live up to his big contract for much of the shortened 2020 MLB season, he settled in late, giving up no earned runs and just four hits over his last 10 innings pitched. Bumgarner will try to carry that form into 2021, and Oh's simulations show him giving up an average of just 2.5 runs in almost six full innings pitched on Thursday. , and all average over one hit in Oh's projections for Arizona. Despite being substantial underdogs, Arizona wins this game in far more simulations than the money line implies, C.J. Miles Jersey making the Diamondbacks a key part of any MLB parlay for Opening Day 2021.How to make MLB Opening Day predictions, parlaysElsewhere on Thursday, Oh has found a key x-factor Jae Crowder Jersey that has him betting against a team that has struggled over the past 22 openers. . So which MLB Opening Day picks should you make on Thursday for a shot at a mammoth 40-1 return? And which home team is a must-fade? .